MS-1020
SIGMA/SML0204 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 1255516-86-9
Empirical Formula (Hill Notation): C21H18N2O3
Molecular Weight: 346.38
Linear Formula: C21H18N2O3
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to tan |
form | powder |
Quality Level | 100 ![]() |
solubility | DMSO: ≥10 mg/mL at 60 °C |
storage temp. | 2-8°C |
Application: | MS-1020 may be used in JAK-3-mediated cell signaling studies. |
Biochem/physiol Actions: | MS-1020 is an ATP-competitive, selective inhibitor of JAK3, thereby blocking downstream STAT signaling. MS-1020 binds directly with JAK3, blocking its catalytic activity. It suppressed IL-2-induced JAK3/STAT5 signaling but not prolactin-induced JAK2/STAT5 signaling. MS-1020 has also been shown to decreases cell survival by inducing apoptosis via downregulating anti-apoptotic gene expression. |
Features and Benefits: | This compound is featured on the JAKs ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 - H319 |
Precautionary statements | P301 + P312 + P330 - P305 + P351 + P338 |
Hazard Codes | Xn |
Risk Statements | 22-36 |
Safety Statements | 26 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |