MS-1020
SIGMA/SML0204 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 1255516-86-9
Empirical Formula (Hill Notation): C21H18N2O3
Molecular Weight: 346.38
Linear Formula: C21H18N2O3
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to tan |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: ≥10 mg/mL at 60 °C |
| storage temp. | 2-8°C |
| Application: | MS-1020 may be used in JAK-3-mediated cell signaling studies. |
| Biochem/physiol Actions: | MS-1020 is an ATP-competitive, selective inhibitor of JAK3, thereby blocking downstream STAT signaling. MS-1020 binds directly with JAK3, blocking its catalytic activity. It suppressed IL-2-induced JAK3/STAT5 signaling but not prolactin-induced JAK2/STAT5 signaling. MS-1020 has also been shown to decreases cell survival by inducing apoptosis via downregulating anti-apoptotic gene expression. |
| Features and Benefits: | This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H319 |
| Precautionary statements | P301 + P312 + P330 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |