SB 328437

SIGMA/SML0207 - ≥98% (HPLC)

Synonym: L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester

CAS Number: 247580-43-4
Empirical Formula (Hill Notation): C₂₁H₁₈N₂O₅
Molecular Weight: 378.38
MDL Number: MFCD16618397
Linear Formula: C₂₁H₁₈N₂O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML0207-5MG	5 mg	$124.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to tan
form	powder
InChI	1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChI key	VMFGCGRAIBLAFY-IBGZPJMESA-N
originator	GlaxoSmithKline
Quality Level	100
SMILES string	COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23
solubility	DMSO: ≥10 mg/mL
storage temp.	2-8°C

Application:	SB 328437 may be used to study CCR3-mediated cell signaling in asthma models.
Biochem/physiol Actions:	SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.
Biochem/physiol Actions:	SB-328437 is a CCR3 Antagonist.
Biochem/physiol Actions:	SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.
Features and Benefits:	This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	5, 25 mg in glass bottle

Hazard Codes	Xn,N
Risk Statements	22-50
Safety Statements	60-61
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352202

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