KYP-2047
SIGMA/SML0208 - ≥95% (HPLC)
Synonym: (2S)
CAS Number: 796874-99-2
Empirical Formula (Hill Notation): C20H25N3O2
Molecular Weight: 339.43
MDL Number: MFCD22201003
Linear Formula: C20H25N3O2
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to light brown |
form | oil |
InChI | 1S/C20H25N3O2/c21-15-17-1 |
InChI key | SPXFAUXQZWJGCJ-ROUUACIJSA |
Quality Level | 100 |
SMILES string | O=C(CCCc1ccccc1)N2CCC[C@H |
storage condition | desiccated |
storage temp. | 2-8°C |
Application: | KYP-2047 may be used in prolyl endopeptidase-mediated cell signaling studies. |
Biochem/physiol Actions: | KYP-2047 clears the α-synuclein aggregates induced by oxidative stress in the neuronal cells. α-synuclein is the main component of Lewy bodies in Parkinson′s disease that cause neuronal cell death and dementia. |
Biochem/physiol Actions: | KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). KYP-2047 has been found to be neuroprotective against glutamate and oxygen, glucose deprivation in vitro. It has also been used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic. |
Features and Benefits: | This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H319 |
Precautionary statements | P305 + P351 + P338 |
Hazard Codes | Xi |
Risk Statements | 36 |
Safety Statements | 26 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |