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KYP-2047

SIGMA/SML0208 - ≥95% (HPLC)

Synonym: (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile

CAS Number: 796874-99-2
Empirical Formula (Hill Notation): C20H25N3O2
Molecular Weight: 339.43
MDL Number: MFCD22201003
Linear Formula: C20H25N3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0208-5MG 5 mg
 $197.00
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45-SML0208-25MG 25 mg
 $794.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
color white to light brown
form oil
InChI 1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
InChI key SPXFAUXQZWJGCJ-ROUUACIJSA-N
Quality Level 100 
SMILES string O=C(CCCc1ccccc1)N2CCC[C@H]2C(=O)N3CCC[C@H]3C#N
storage condition desiccated
storage temp. 2-8°C
Application: KYP-2047 may be used in prolyl endopeptidase-mediated cell signaling studies.
Biochem/physiol Actions: KYP-2047 clears the α-synuclein aggregates induced by oxidative stress in the neuronal cells. α-synuclein is the main component of Lewy bodies in Parkinson′s disease that cause neuronal cell death and dementia.
Biochem/physiol Actions: KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine).
Biochem/physiol Actions: KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). KYP-2047 has been found to be neuroprotective against glutamate and oxygen, glucose deprivation in vitro. It has also been used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.
Features and Benefits: This compound is featured on the Neuropeptidases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H319
Precautionary statements P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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