BMS-299897
SIGMA/SML0210 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 290315-45-6
Empirical Formula (Hill Notation): C24H21ClF3NO4S
Molecular Weight: 511.94
Linear Formula: C24H21ClF3NO4S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | −20°C |
| Application: | BMS-299897 has been used as an γ-secretase inhibitor to stop high glucose (HG) mediated amyloid β-peptide (Aβ) secretion. |
| Biochem/physiol Actions: | BMS-299897 is a potent inhibitor of γ-secretase. The comound is 15-fold more selective for inhibiting the cleavage of β-amyloid precursor protein over Notch cleavage (IC50s 7.1 and 105.9, respectively). In vivo, BMS-299897 blocks the formation of Aβ40 and Aβ42 in the brain and CSF without affecting maturation of CD8+ T cells or intestinal goblet cells, suggesting Notch signalling was not significantly inhibited. |
| Biochem/physiol Actions: | BMS-299897 may be used as a therapeutic for Alzheimer′s disease. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |