Synonym: 1-Butyl-3-(3-hydroxypropyl)-8-(3-noradamantyl)xanthine; 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione; PSB-36
CAS Number: 524944-72-7
Empirical Formula (Hill Notation): C21H30N4O3
Molecular Weight: 386.49
Linear Formula: C21H30N4O3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to tan |
| form |
powder |
| InChI |
1S/C21H30N4O3/c1-2-3-5-25-18(27)16-17(24(20(25)28)6-4-7-26)23-19(22-16)21-11-13-8-14(12-21)10-15(21)9-13/h13-15,26H,2-12H2,1H3,(H,22,23)/t13-,14+,15-,21- |
| InChI key |
CIBIXJYFYPFMTN-FZUGUKJMSA-N |
| Quality Level |
100  |
| SMILES string |
CCCCN1C(=O)N(CCCO)c2nc([nH]c2C1=O)C34C[C@@H]5C[C@@H](C[C@H]3C5)C4 |
| solubility |
DMSO: ≥20 mg/mL |
| storage condition |
desiccated |
| storage temp. |
2-8°C |
| Application: |
PSB36 was used to examine the role of A1-adenosine receptor-mediated cell signaling in CD39 expression in pancreatic b-cells of streptozotocin-induced diabetic mice. |
| Biochem/physiol Actions: |
Inhibition of A1 adenosine receptor by PSB36 modulates the spinal antinociception in animal models. |
| Biochem/physiol Actions: |
PSB36 is a very potent, selective antagonist of the adenosine A1 receptor. The compound selectivity (Ki) for human A1, A2A, A2B and A3 receptors is 0.7, 980, 187 and 2300 respectively. PSB36 is considerably more potent that DPCPX (EC50 0.012 nM vs 2.9 nM) |
| Features and Benefits: |
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
10, 50 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
