MC2050 hydrate
SIGMA/SML0213 - ≥98% (HPLC)
Synonym: 2-
Empirical Formula (Hill Notation): C19H21N5OS·2HCl · xH2O
Molecular Weight: 440.39 (anhydrous basis)
MDL Number: MFCD21608523
Linear Formula: C19H21N5OS·2HCl · xH2O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C19H21N5OS.2ClH.H2O/c2 |
InChI key | LMZZPRHHBPFDGE-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | O.Cl.Cl.O=C1NC(SCCN2CCN(C |
solubility | H2O: ≥5 mg/mL at warmed to 60 °C |
storage temp. | 2-8°C |
Application: | MC2050 hydrate may be used in cell signaling studies. |
Biochem/physiol Actions: | MC2050 is a water-soluble PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells. |
Features and Benefits: | This compound is featured on the Caspases ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |