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MC2050 hydrate

SIGMA/SML0213 - ≥98% (HPLC)

Synonym: 2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate

Empirical Formula (Hill Notation): C19H21N5OS·2HCl · xH2O
Molecular Weight: 440.39 (anhydrous basis)
MDL Number: MFCD21608523
Linear Formula: C19H21N5OS·2HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0213-5MG 5 mg
 $144.00
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45-SML0213-25MG 25 mg
 $771.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2
InChI key LMZZPRHHBPFDGE-UHFFFAOYSA-N
Quality Level 100 
SMILES string O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14
solubility H2O: ≥5 mg/mL at warmed to 60 °C
storage temp. 2-8°C
Application: MC2050 hydrate may be used in cell signaling studies.
Biochem/physiol Actions: MC2050 is a PARP-1 inhibitor
Biochem/physiol Actions: MC2050 is a water-soluble PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.
Features and Benefits: This compound is featured on the Caspases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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