GSK2334470

SIGMA/SML0217 - ≥98% (HPLC)

Synonym: (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide

CAS Number: 1227911-45-6
Empirical Formula (Hill Notation): C₂₅H₃₄N₈O
Molecular Weight: 462.59
MDL Number: MFCD21608525
Linear Formula: C₂₅H₃₄N₈O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0217-5MG	5 mg	$151.00 1/EA	Add To Favorites
45-SML0217-25MG	25 mg	$411.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to light brown
form	powder
InChI	1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1
InChI key	QLPHOXTXAKOFMU-WBVHZDCISA-N
Quality Level	100
SMILES string	CNc1nc(cc(n1)-c2ccc3c(N)n[nH]c3c2)N4C[C@H](CC[C@H]4C)C(=O)NC5CCCCC5
solubility	DMSO: ≥10 mg/mL
storage temp.	2-8°C

Application:	GSK2334470 has been used as an inhibitor of 3-phosphoinositide dependent protein kinase-1 (PDK-1) in: • Treg cells, to identify regulators of interleukin 2 (IL-2)– signal transducer and activator of transcription 5 (STAT5) signaling • glycodelin-transfected HEC-1B human endometrial adenocarcinoma cells. • HeLa and Hs578T cells to test its effect on formylglycinamidine ribonucleotide synthase (FGAMS) assembly
Biochem/physiol Actions:	GSK2334470 (GSK-470) mediates cell cycle arrest. It also inhibits cellular proliferation and induces apoptosis in cancer cells.
Biochem/physiol Actions:	GSK2334470 is a highly specific and potent inhibitor of PDK1
Biochem/physiol Actions:	GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). GSK2334470 can be used in cells to ablate T-loop phosphorylation and activation SGK, S6K1 and RSK as well as suppress the activation of Akt.
Other Notes:	GSK2334470 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK2334470 probe summary on the Chemical Probes Portal website.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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