Piperlongumine
SIGMA/SML0221 - ≥97% (HPLC)
Synonym: 5,6-
CAS Number: 20069-09-4
Empirical Formula (Hill Notation): C17H19NO5
Molecular Weight: 317.34
MDL Number: MFCD00075706
Linear Formula: C17H19NO5
Product Type: Chemical
| assay | ≥97% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C17H19NO5/c1-21-13-10- |
| InChI key | VABYUUZNAVQNPG-BQYQJAHWSA |
| Quality Level | 100  |
| SMILES string | COc1cc(C=CC(=O)N2CCC=CC |
| solubility | DMSO: ≥5 mg/mL at warmed to 60 °C |
| storage temp. | 2-8°C |
| Application: | Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro. |
| Application: | Piperlongumine has been used: • as a pro-oxidant drug to treat HepG2 cells expressing zinc finger protein (ZNF)32 • to test its anti-neuroinflammatory effects in BV2 microglial cells • to test its inhibitory effect on human gastric cancer cell lines |
| Biochem/physiol Actions: | Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases. |
| General description: | Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |