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Zoledronic acid monohydrate

SIGMA/SML0223 - ≥98% (HPLC)

Synonym: P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate; Zoledronate monohydrate; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate

CAS Number: 165800-06-6
Empirical Formula (Hill Notation): C5H10N2O7P2·H2O
Molecular Weight: 290.10
MDL Number: MFCD08448695
Linear Formula: C5H10N2O7P2·H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0223-10MG 10 mg
 $123.00
1/EA		 Add To Favorites
45-SML0223-50MG 50 mg
 $497.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0223-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: SML0223-50MG

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChI key FUXFIVRTGHOMSO-UHFFFAOYSA-N
Quality Level 100 
SMILES string O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
solubility H2O: ≥2 mg/mL
storage condition desiccated
  protect from light
storage temp. 2-8°C
Application: Zoledronic acid monohydrate has been used:
•  as an inhibitor for cell proliferation in glioblastoma, breast cancer tumor and prostate cancer cell line LAPC4
•  as a conjugate with D,L-lactide 75: glycolide 25 (PLGA) to analyze its bone formation functionality in distal femur
•  as an inhibitor for farnesyl diphosphate synthase enzyme in glioblastoma cells
Biochem/physiol Actions: Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.
Biochem/physiol Actions: Zoledronic acid (zoledronate) is a bone resorption inhibitor, an inhibitor of farnesyl diphosphate synthase
Packaging: 10, 50 mg in glass bottle
Preparation Note: This product is extremely unstable in solution and should be used shortly after reconstitution. If storage of the solution is necessary it can be held at 2-8ºC for no more than 24 hours.
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352204

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