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LY255582

SIGMA/SML0225 - ≥98% (HPLC)

Synonym: (3R,4R)-3,4-Dimethyl-1-[(3S)-3-hydroxy-3-cyclohexyl-propyl]-4-(3-hydroxyphenyl)piperidine; (aS,3R,4R)-a-Cyclohexyl-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinepropanol; LY-255582

CAS Number: 119193-09-8
Empirical Formula (Hill Notation): C22H35NO2
Molecular Weight: 345.52
MDL Number: MFCD00878181
Linear Formula: C22H35NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0225-5MG 5 mg
 $136.00
1/EA		 Add To Favorites
45-SML0225-25MG 25 mg
 $532.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML0225-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C22H35NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h6,9-10,15,17-18,21,24-25H,3-5,7-8,11-14,16H2,1-2H3/t17-,21-,22+/m0/s1
InChI key LVVHEFJXPXAUDD-BULFRSBZSA-N
originator Eli Lilly
Quality Level 100 
SMILES string C[C@H]1CN(CC[C@H](O)C2CCCCC2)CC[C@@]1(C)c3cccc(O)c3
solubility DMSO: ≥15 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: LY255582 may be used in opioid receptor-mediated cell signaling studies.
Biochem/physiol Actions: LY255582 inhibits the diet-associated increases in mesolimbic dopamine levels and reduces the consumption of highly-palatable food intake.
Biochem/physiol Actions: LY255582 is a centrally active opioid receptor antagonist
Biochem/physiol Actions: LY255582 is a centrally active opioid receptor antagonist (defined as an inverse agonist in 2011 JPET paper) that inhibited weight gain in obese Zucker rats over 30 days. It is more that 5-fold selective for mu opioid receptor compared to kappa opioid receptors and 13-fold selective over delta opioid receptors.
Features and Benefits: This compound is featured on the Opioid Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Eli Lilly . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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