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CIQ

SIGMA/SML0229 - ≥98% (HPLC)

Synonym: (3-Chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone

CAS Number: 486427-17-2
Empirical Formula (Hill Notation): C26H26ClNO5
Molecular Weight: 467.94
Linear Formula: C26H26ClNO5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0229-5MG 5 mg
 $101.00
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45-SML0229-25MG 25 mg
 $594.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
InChI key VYMILMYEENZHAR-UHFFFAOYSA-N
Quality Level 100 
SMILES string Clc1cc(ccc1)C(=O)N2CCc3c(cc(c(c3)OC)OC)C2COc4ccc(cc4)OC
solubility DMSO: ≥10 mg/mL at warmed to 60 °C
storage temp. 2-8°C
Biochem/physiol Actions: CIQ is a selective NR2C/NR2D-containing NMDA potentiator
Biochem/physiol Actions: CIQ is positive allosteric modulator of NR2C/NR2D subunit containing NMDA receptors. CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. The compound does not alter the EC50 values for glutamate or glycine on channel opening.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Glutamate Receptors (Ion Channel Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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