CIQ

SIGMA/SML0229 - ≥98% (HPLC)

Synonym: (3-Chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone

CAS Number: 486427-17-2
Empirical Formula (Hill Notation): C₂₆H₂₆ClNO₅
Molecular Weight: 467.94
Linear Formula: C₂₆H₂₆ClNO₅
Product Type: Chemical

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
InChI key	VYMILMYEENZHAR-UHFFFAOYSA-N
Quality Level	100
solubility	DMSO: ≥10 mg/mL at warmed to 60 °C
storage temp.	2-8°C

Biochem/physiol Actions:	CIQ is positive allosteric modulator of NR2C/NR2D subunit containing NMDA receptors. CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC₅₀ = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. The compound does not alter the EC₅₀ values for glutamate or glycine on channel opening.
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable