Synonym: 8-[[4-(4-Fluorophenyl)-4-oxobutyl]thio]-1,3,6,9-tetrahydro-1,3-dimethyl-6-thioxo-2H-purin-2-one
CAS Number: 6505-98-2
Empirical Formula (Hill Notation): C17H17FN4O2S2
Molecular Weight: 392.47
Linear Formula: C17H17FN4O2S2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
light yellow to yellow |
| form |
powder |
| InChI |
1S/C17H17FN4O2S2/c1-21-14-13(15(25)22(2)17(21)24)19-16(20-14)26-9-3-4-12(23)10-5-7-11(18)8-6-10/h5-8H,3-4,9H2,1-2H3,(H,19,20) |
| InChI key |
BEBDNAPSDUYCHM-UHFFFAOYSA-N |
| Quality Level |
100  |
| solubility |
DMSO: ≥10 mg/mL at warmed to 60 °C |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
TPSF is a noncompetitive, potent inhibitor of estrogen receptor α, that does not compete with estrogen for binding to Erα. The compound has low toxicity and selectively targets E2-ERα-dependent cell growth. TPSF is effective in cells that become tamoxifen-resistant. It appears that down-regulation of ERα by TPSF is at list partially dependent to enhancement of proteasome-dependent degradation of ERα. |
| Features and Benefits: |
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC); ≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
51111800 |
