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Ro 61-8048

SIGMA/SML0233 - ≥98% (HPLC)

Synonym: 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide; 3,4-Dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide; Ro-61-8048

CAS Number: 199666-03-0
Empirical Formula (Hill Notation): C17H15N3O6S2
Molecular Weight: 421.45
MDL Number: MFCD11040807
Linear Formula: C17H15N3O6S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0233-5MG 5 mg
 $146.00
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45-SML0233-25MG 25 mg
 $577.00
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assay ≥98% (HPLC)
color faintly yellow to yellow
form powder
InChI 1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)
InChI key NDPBMCKQJOZAQX-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1ccc(cc1OC)S(=O)(=O)Nc2nc(cs2)-c3cccc(c3)[N+]([O-])=O
solubility DMSO: ≥15 mg/mL
storage temp. 2-8°C
Application: Ro 61-8048 has been used as a kynurenine 3-monooxygenase (KMO) inhibitor to study its effects on nicotinamide adenine dinucleotide (NAD+) concentration in hepatocytes of mice.
Biochem/physiol Actions: Inhibition of kynurenine 3-hydroxylase by Ro 61-8048 reduces the episodes of dystonia and dyskinesias induced by decreased levels of kynurenic acid.
Biochem/physiol Actions: Ro 61-8048 is a potent kynurenine 3-monooxygenase (KMO) inhibitor
Biochem/physiol Actions: Ro 61-8048 is an inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain.
Packaging: 5, 25 mg in glass bottle
Hazard Codes T
Risk Statements 25-36
Safety Statements 26-45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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