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Adefovir

SIGMA/SML0240 - ≥98% (HPLC)

Synonym: GS 0393; GS-393; P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid, 9-(2-phosphonylmethoxyethyl)adenine; PMEA

CAS Number: 106941-25-7
Empirical Formula (Hill Notation): C8H12N5O4P
Molecular Weight: 273.19
MDL Number: MFCD00866943
Linear Formula: C8H12N5O4P
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0240-10MG 10 mg
 $121.00
1/EA		 Add To Favorites
45-SML0240-50MG 50 mg
 $486.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
InChI key SUPKOOSCJHTBAH-UHFFFAOYSA-N
Quality Level 100 
SMILES string Nc1ncnc2n(CCOCP(O)(O)=O)cnc12
solubility 0.1 M NaOH: ≥5 mg/mL
storage condition desiccated
storage temp. −20°C
Application: Adefovir has been used to study its anti-retro viral effect on porcine endogenous retrovirus (PERV) activity.
Biochem/physiol Actions: Adefovir is an antiviral and is the active form of adefovir dipivoxyl
Biochem/physiol Actions: Adefovir is an antiviral drug that after intracellular conversion to adefovir diphosphate inhibits hepatitis B virus (HBV) DNA polymerase (reverse transcriptase).
Biochem/physiol Actions: Adefovir, also known as 9-(2-phosphonylmethoxyethyl)adenine (PMEA), is an acyclic nucleoside phosphonate. It has a potential to hinder the in vitro replication of several retroviruses such as human immunodeficiency virus (HIV)-1 and HIV-2, simian immunodeficiency virus (SIV), simian AIDS-related virus (SRV), feline immunodeficiency virus (FIV). Thus, Adefovir may be used as a therapeutic for various retrovirus infections including acquired immunodeficiency syndrome (AIDS).
Features and Benefits: This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox  and Cyclic Nucleotide  products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Adenylyl cyclases  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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