JZL195
SIGMA/SML0257 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 1210004-12-8
Empirical Formula (Hill Notation): C24H23N3O5
Molecular Weight: 433.46
MDL Number: MFCD18382122
Linear Formula: C24H23N3O5
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C24H23N3O5/c28-24(32-2 |
| InChI key | QNYRAEKLMNDRFY-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [O-][N+](=O)c1ccc(OC(=O)N |
| solubility | DMSO: ≥5 mg/mL at warmed |
| storage temp. | −20°C |
| Application: | JZL195 has been used: • as a selective inhibitor of endocannabinoid (eCB) clearance enzymes to induce in vivo long-term depression at CA3-CA1 synapses and at prelimbic (PrL)-nucleus accumbens (NAc)synapses, to study the neuroprotective action of eCB • to inhibit the action of hydrolytic enzymes that limit eCB activity, to study the effect of 2-linoleoylglycerol (2-LG) on the human CB1 receptor activity • as a dual fatty acid amide hydrolase (FAAH)/monoacylglycerol lipase (MAGL) inhibitor to study its dose-related antipruritic effect on the serotonin (5-HT)-induced scratching model |
| Biochem/physiol Actions: | JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. IC50 values are 2 nM for MAGL and 4 nM for FAAH. JZL195 has been shown to inhibit endocannabinoid hydrolysis and elevate 2-AG and AEA levels in vivo. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS09 |
| Signal word | Warning |
| Hazard statements | H400 |
| Precautionary statements | P273 |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |