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AEG 3482

SIGMA/SML0264 - ≥98% (HPLC)

Synonym: 6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

CAS Number: 63735-71-7
Empirical Formula (Hill Notation): C10H8N4O2S2
Molecular Weight: 280.33
MDL Number: MFCD02064987
Linear Formula: C10H8N4O2S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0264-5MG 5 mg
 $114.00
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assay ≥98% (HPLC)
color faintly yellow to dark yellow
form powder
InChI 1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)
InChI key MQUYTXDAVCOCMX-UHFFFAOYSA-N
Quality Level 100 
SMILES string NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3
solubility DMSO: ≥15 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.
Biochem/physiol Actions: AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.
Biochem/physiol Actions: AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.
Features and Benefits: This compound is featured on the MAPKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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