BIP-135
SIGMA/SML0265 - ≥95% (HPLC)
Synonym: 3-
CAS Number: 941575-71-9
Empirical Formula (Hill Notation): C21H13BrN2O3
Molecular Weight: 421.24
MDL Number: MFCD16495779
Linear Formula: C21H13BrN2O3
Product Type: Chemical
assay | ≥95% (HPLC) |
color | light orange to dark orange |
form | powder |
InChI | 1S/C21H13BrN2O3/c1-24-9-1 |
InChI key | QKQJCKAXFJBYKJ-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | Cn1cc(C2=C(C(=O)NC2=O)c3c |
solubility | DMSO: ≥15 mg/mL |
storage temp. | room temp |
Biochem/physiol Actions: | BIP-135 is a potent inhibitor of glycogen synthase kinase-3 (GSK3) found to be relatively selective for GSK-3β (21 nM) over GSK-3α with modest activity toward PKCβ (β1: 980 nM; β2: 219 nM), DYRK1B (590 nM), and PI3Kα (870 nM). BIP-135 was found to be a superior neuroprotective agent in a cortical neuron model of oxidative stress over other GSK-3 inhibitors, such as AR-A011418 and SB216763. In a mouse model of spinal muscular atrophy (SMA), BIP-135 elevated SMN protein levels in vitro and extended median survival. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301 + P310 |
Hazard Codes | T |
Risk Statements | 25 |
Safety Statements | 45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | room temp |
UNSPSC | 12352200 |