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AZD1152-HQPA

SIGMA/SML0268 - ≥98% (HPLC)

Synonym: 3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide

CAS Number: 722544-51-6
Empirical Formula (Hill Notation): C26H30FN7O3
Molecular Weight: 507.56
MDL Number: MFCD10687152
Linear Formula: C26H30FN7O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0268-10MG 10 mg
 $117.00
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45-SML0268-50MG 50 mg
 $471.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
InChI key QYZOGCMHVIGURT-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1
solubility DMSO: >15 mg/mL
storage temp. 2-8°C
Application: AZD1152-HQPA has been used as a specific inhibitor of aurora kinase B (AURKB) to examine the cell cycle stage the IRG (hit compound that induces an irregular nuclear shape)-treated cells accumulate and become senescent and also to study the roles of cyclin-dependent kinase 6 (CDK6) and AURKB in restricting enterovirus 71 (EV71) infection.
Application: AZD1152-HQPA has been used:
• for the dose dependent inhibition of aurora kinase B (AURKB)
• as a component to identify that, replication timing regulatory factor 1 (RIF1) and protein phosphatase 1 (PP1) are critical for the regulation of abscission timing in human cells
• as a component to study the relevance of AURKB as a cancer therapeutic target
Biochem/physiol Actions: AZD1152-HQPA is a selective aurora-B kinase inhibitor; anti-cancer agent.
Biochem/physiol Actions: AZD1152-HQPA is the active metabolite of AZD-1152, a potent selective Aurora Kinase B inhibitor. AZD1152 is 50-fold selective for Aurora kinase B over Aurora kinase C and over 1000-fold selective for Aurora kinase B over Aurora Kinase A. (IC50s: aurora-A, 1,369 nmol/L; aurora-B, 0.36 nmol/L; aurora-C, 17.0 nmol/L). It is converted in plasma to the active form AZD1152-HQPA, which has been shown to have antineoplastic activity in a variety of animal models and human cancer cell lines.
Other Notes: AZD1152-HQPA has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the AZD1152-HPQA probe summary  on the Chemical Probes Portal website.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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