Nitisinone

SIGMA/SML0269 - ≥95% (HPLC)

Synonym: 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; NTBC; Nitisone; SC 0735

CAS Number: 104206-65-7
Empirical Formula (Hill Notation): C₁₄H₁₀F₃NO₅
Molecular Weight: 329.23
MDL Number: MFCD01752192
Linear Formula: C₁₄H₁₀F₃NO₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0269-10MG	10 mg	$113.00 1/EA	Add To Favorites
45-SML0269-50MG	50 mg	$441.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	white to brown
form	powder
InChI	1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
InChI key	OUBCNLGXQFSTLU-UHFFFAOYSA-N
Quality Level	100
SMILES string	[O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F
solubility	DMSO: ≥5 mg/mL
storage temp.	−20°C

Application:	Nitisinone has been used: • to induce liver injury • to treat Ixodes scapularis tick cells to inhibit the activity of hydroxyphenylpyruvate dioxygenase • in supplemented water to block the accumulation of toxic metabolites in human hepatocyte engrafted mice • to study its effect on bacterial pyomelanin production
Biochem/physiol Actions:	Nitisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Nitisinone is used in the treatment of hereditary tyrosinemia type 1, where it blocks the degradation of tyrosine into harmful substances.
Packaging:	10, 50 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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