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Nitisinone

SIGMA/SML0269 - ≥95% (HPLC)

Synonym: 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione; NTBC; Nitisone; SC 0735

CAS Number: 104206-65-7
Empirical Formula (Hill Notation): C14H10F3NO5
Molecular Weight: 329.23
MDL Number: MFCD01752192
Linear Formula: C14H10F3NO5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0269-10MG 10 mg
 $116.00
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45-SML0269-50MG 50 mg
 $453.00
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assay ≥95% (HPLC)
color white to brown
form powder
InChI 1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
InChI key OUBCNLGXQFSTLU-UHFFFAOYSA-N
Quality Level 100 
SMILES string [O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F
solubility DMSO: ≥5 mg/mL
storage temp. −20°C
Application: Nitisinone has been used:
• to induce liver injury
• to treat Ixodes scapularis tick cells to inhibit the activity of hydroxyphenylpyruvate dioxygenase
• in supplemented water to block the accumulation of toxic metabolites in human hepatocyte engrafted mice
• to study its effect on bacterial pyomelanin production
Biochem/physiol Actions: Nitisinone is a competitive and reversible inhibitor of 4-Hydroxyphenylpyruvate oxidase (dioxygenase).
Biochem/physiol Actions: Nitisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Nitisinone is used in the treatment of hereditary tyrosinemia type 1, where it blocks the degradation of tyrosine into harmful substances.
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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