Nitisinone
SIGMA/SML0269 - ≥95% (HPLC)
Synonym: 2-
CAS Number: 104206-65-7
Empirical Formula (Hill Notation): C14H10F3NO5
Molecular Weight: 329.23
MDL Number: MFCD01752192
Linear Formula: C14H10F3NO5
Product Type: Chemical
assay | ≥95% (HPLC) |
color | white to brown |
form | powder |
InChI | 1S/C14H10F3NO5/c15-14(16, |
InChI key | OUBCNLGXQFSTLU-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | [O-][N+](=O)c1cc(ccc1C(=O |
solubility | DMSO: ≥5 mg/mL |
storage temp. | −20°C |
Application: | Nitisinone has been used: • to induce liver injury • to treat Ixodes scapularis tick cells to inhibit the activity of hydroxyphenylpyruvate dioxygenase • in supplemented water to block the accumulation of toxic metabolites in human hepatocyte engrafted mice • to study its effect on bacterial pyomelanin production |
Biochem/physiol Actions: | Nitisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Nitisinone is used in the treatment of hereditary tyrosinemia type 1, where it blocks the degradation of tyrosine into harmful substances. |
Packaging: | 10, 50 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |