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VER-155008

SIGMA/SML0271 - ≥98% (HPLC)

Synonym: 5′-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

CAS Number: 1134156-31-2
Empirical Formula (Hill Notation): C25H23Cl2N7O4
Molecular Weight: 556.40
MDL Number: MFCD18086892
Linear Formula: C25H23Cl2N7O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0271-5MG 5 mg
 $127.00
1/EA		 Add To Favorites
45-SML0271-25MG 25 mg
 $531.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1
InChI key ZXGGCBQORXDVTE-UMCMBGNQSA-N
Quality Level 100 
SMILES string Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12
solubility DMSO: >10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:
• to study its effects on human embryonic kidney 293 (HEK293T) cells
• to study its effects on viral mRNA synthesis and protein expression in Vero E6 cells
• to determine its effects on the attenuation of seizures in rats
Biochem/physiol Actions: VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells.
Biochem/physiol Actions: VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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