VER-155008
SIGMA/SML0271 - ≥98% (HPLC)
Synonym: 5′-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CAS Number: 1134156-31-2
Empirical Formula (Hill Notation): C25H23Cl2N7O4
Molecular Weight: 556.40
MDL Number: MFCD18086892
Linear Formula: C25H23Cl2N7O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to light brown |
form | powder |
InChI | 1S/C25H23Cl2N7O4/c26-16-6 |
InChI key | ZXGGCBQORXDVTE-UMCMBGNQSA |
Quality Level | 100 ![]() |
SMILES string | Nc1ncnc2n([C@@H]3O[C@H](C |
solubility | DMSO: >10 mg/mL |
storage condition | desiccated |
storage temp. | 2-8°C |
Application: | VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor: • to study its effects on human embryonic kidney 293 (HEK293T) cells • to study its effects on viral mRNA synthesis and protein expression in Vero E6 cells • to determine its effects on the attenuation of seizures in rats |
Biochem/physiol Actions: | VER-155002 is a small molecule, ATP-derivative inhibitor of HSP70 (IC50 = 500 nM). The compound inhibits proliferation of several colon and breast cancer cell lines, induces caspase dependent apoptosis in BT474 cells and down regulates expression of Her2 and Raf-1 in HCT116 cells. |
Biochem/physiol Actions: | VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC). |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |