Etifoxine hydrochloride

SIGMA/SML0272 - ≥98% (HPLC)

Synonym: 6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride; 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride; HOE-36801 hydrochloride

CAS Number: 56776-32-0
Empirical Formula (Hill Notation): C₁₇H₁₇ClN₂O · HCl
Molecular Weight: 337.24
EC Number: 260-380-0
MDL Number: MFCD18086857
Linear Formula: C₁₇H₁₇ClN₂O · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0272-10MG	10 mg	$182.00 1/EA	Add To Favorites
45-SML0272-50MG	50 mg	$696.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C17H17ClN2O.ClH/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12;/h4-11H,3H2,1-2H3,(H,19,20);1H
InChI key	SCBJXEBIMVRTJE-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cl.CCNC1=Nc2ccc(Cl)cc2C(C)(O1)c3ccccc3
solubility	DMSO: ≥5 mg/mL
storage condition	desiccated
storage temp.	−20°C

Application:	Etifoxine hydrochloride has been used as a γ-aminobutyric acid (GABA)-receptor agonist to study its effects on insulin expression in α cell line (αTC1)
Biochem/physiol Actions:	Etifoxine is an anxiolytic anticonvulsant, which binds to TSPO and GABAA receptor β2 and β3 subunits.
Biochem/physiol Actions:	Etifoxine is an anxiolytic anticonvulsant, which promotes axonal regeneration. It binds to β2 and β3 subunits of the GABAA receptor complex, a different target site to benzodiazepines, and binds to the translocator protein (18 kDa) TSPO, formerly known as the peripheral or mitochondrial benzodiazepine receptor. TSPO carries cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step of steroidogenesis. Whereas, its anxiolytic effects involve GABAA receptors and TSPO, etifoxine′s neuroregenerative effects mainly involve TSPO.
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	10, 50 mg in glass bottle

Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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