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VAS2870

SIGMA/SML0273 - ≥97% (HPLC)

Synonym: 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide; 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine; VAS 2870; VAS-2870

CAS Number: 722456-31-7
Empirical Formula (Hill Notation): C18H12N6OS
Molecular Weight: 360.39
MDL Number: MFCD03407188
Linear Formula: C18H12N6OS
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0273-5MG 5 mg
 $93.40
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45-SML0273-25MG 25 mg
 $380.00
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assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2
InChI key HZSOKHVVANONPV-UHFFFAOYSA-N
Quality Level 100 
SMILES string C(c1ccccc1)n2nnc3c(Sc4nc5ccccc5o4)ncnc23
solubility DMSO: ≥5 mg/mL
storage temp. room temp
Application: VAS2870 has been used as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor:
• to study the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly
•  to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed mice
• to reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes
Biochem/physiol Actions: In addition to NOX4 inhibition, VAS2870 is also known to supress the reactive oxygen species (ROS) production in several cell types. It effectively impairs cell growth and increases apoptosis induced by transforming growth factor β (TGF-β) in liver cancer cells. Thus, inhibition of NOX enzymes by VAS2870 may be considered as a potential therapeutic strategy for liver cancer.
Biochem/physiol Actions: VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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