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BD 1063 dihydrochloride

SIGMA/SML0276 - ≥98% (HPLC)

Synonym: 1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride; BD1063 dihydrochloride

CAS Number: 206996-13-6
Empirical Formula (Hill Notation): C13H18Cl2N2 · 2HCl
Molecular Weight: 346.12
MDL Number: MFCD00792740
Linear Formula: C13H18Cl2N2 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0276-5MG 5 mg
 $116.00
1/EA		 Add To Favorites
45-SML0276-25MG 25 mg
 $453.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
InChI key NXFDBTLQOARIMH-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.CN1CCN(CC1)CCc2ccc(Cl)c(Cl)c2
solubility H2O: >15 mg/mL
storage condition desiccated
storage temp. room temp
Application: BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:
• to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells
• in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
• to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells
Biochem/physiol Actions: BD 1063 is a potent sigma(1) receptor antagonist.
Biochem/physiol Actions: BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.
Other Notes: air sensitive
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H319
Precautionary statements P305 + P351 + P338
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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