BD 1063 dihydrochloride
SIGMA/SML0276 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 206996-13-6
Empirical Formula (Hill Notation): C13H18Cl2N2 · 2HCl
Molecular Weight: 346.12
MDL Number: MFCD00792740
Linear Formula: C13H18Cl2N2 · 2HCl
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C13H18Cl2N2.2ClH/c1-16 |
| InChI key | NXFDBTLQOARIMH-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.Cl.CN1CCN(CC1)CCc2ccc( |
| solubility | H2O: >15 mg/mL |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist: • to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells • in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl) • to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells |
| Biochem/physiol Actions: | BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects. |
| Other Notes: | air sensitive |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |