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Methylnaltrexone bromide

SIGMA/SML0277 - ≥97% (HPLC)

Synonym: 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium bromide; MNTX; Methylnaltrexonium; Mrz-2663; N-Methylnaltrexone; Naltrexone MB; Quaternary ammonium naltrexone

CAS Number: 73232-52-7
Empirical Formula (Hill Notation): C21H26NO4 · Br
Molecular Weight: 436.34
MDL Number: MFCD06407831
Linear Formula: C21H26NO4 · Br
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0277-5MG 5 mg
 $113.00
1/EA		 Add To Favorites
45-SML0277-25MG 25 mg
 $617.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21-,22?;/m1./s1
InChI key IFGIYSGOEZJNBE-KNLJMPJLSA-N
Quality Level 100 
shipped in wet ice
SMILES string [Br-].C[N@+]1(CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@]2(O)CCC4=O)c35)CC6CC6
solubility H2O: ≥5 mg/mL
storage condition desiccated
storage temp. −20°C
Application: Methylnaltrexone bromide has been used as a drug to measure plasma protein binding (PPB), permeability (Pm) and the membrane coefficient (KIAM) for the prediction of blood brain barrier (BBB) penetration. It is also used as a mu-opioid receptor (MOR) antagonist to abrogate morphine tolerance and opioid-induced hyperalgesia (OIH).
Biochem/physiol Actions: Methylnaltrexone bromide is a narcotic antagonist.
Biochem/physiol Actions: Methylnaltrexone bromide is a narcotic antagonist. It is a peripheral mu-opiod receptor antagonist that cannot cross the blood-brain barrier. It reverses many opioid side-effects without interfering with pain relief.
Features and Benefits: This compound is featured on the Opioid Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Methylnaltrexone does not cross blood brain barrier and does not affect the opioid effects in the brain, such as analgesia. It is used to treat opioid-induced constipation (OIC).
Packaging: 5, 25 mg in glass bottle
Hazard Codes T,N
Risk Statements 25-50
Safety Statements 45-61
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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