SR 48692
SIGMA/SML0278 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 146362-70-1
Empirical Formula (Hill Notation): C32H31ClN4O5
Molecular Weight: 587.07
Linear Formula: C32H31ClN4O5
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C32H31ClN4O5/c1-41-27- |
InChI key | DYLJVOXRWLXDIG-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | COc1cccc(OC)c1-c2cc(nn2-c |
solubility | DMSO: ≥2 mg/mL (warmed) |
storage temp. | −20°C |
Application: | SR 48692 has been used as a neurotensin high-affinity receptor 1 (NTSR1) antagonist: • to explore the function of NTSR1 in glioblastoma (GBM) cells • to determine the roles of neurotensin (NT) in the regulation of bile acid (BA) uptake, in vivo • to explore the involvement of NTSR1 versus NTSR2 in mice |
Biochem/physiol Actions: | SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex. |
Features and Benefits: | This compound is featured on the Neurotensin Receptors ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |