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SR 48692

SIGMA/SML0278 - ≥98% (HPLC)

Synonym: 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid; Meclinertant

CAS Number: 146362-70-1
Empirical Formula (Hill Notation): C32H31ClN4O5
Molecular Weight: 587.07
Linear Formula: C32H31ClN4O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0278-5MG 5 mg
 $135.00
1/EA		 Add To Favorites
45-SML0278-25MG 25 mg
 $536.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)
InChI key DYLJVOXRWLXDIG-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1cccc(OC)c1-c2cc(nn2-c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(C6)CC5C7)C(O)=O
solubility DMSO: ≥2 mg/mL (warmed)
storage temp. −20°C
Application: SR 48692 has been used as a neurotensin high-affinity receptor 1 (NTSR1) antagonist:
• to explore the function of NTSR1 in glioblastoma (GBM) cells
•  to determine the roles of neurotensin (NT) in the regulation of bile acid (BA) uptake, in vivo
•  to explore the involvement of NTSR1 versus NTSR2 in mice
Biochem/physiol Actions: SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.
Biochem/physiol Actions: SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist.
Features and Benefits: This compound is featured on the Neurotensin Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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