Bexarotene
SIGMA/SML0282 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 153559-49-0
Empirical Formula (Hill Notation): C24H28O2
Molecular Weight: 348.48
MDL Number: MFCD00932428
Linear Formula: C24H28O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C24H28O2/c1-15-13-20-2 |
| InChI key | NAVMQTYZDKMPEU-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | C=C(C1=CC=C(C(O)=O)C=C1)C |
| solubility | DMSO: ≥15 mg/mL (warmed) |
| storage temp. | −20°C |
| Application: | Bexarotene has been used as retinoid x receptor (RXR) agonist: • to study its effect on human oral squamous cell carcinoma (OSCC) cell lines • to test for cooperative cell killing of cutaneous T cell lymphoma (CTCL) with 966 • as a standard in HPLC for determining its potential impurities in drug substances and drug products |
| Application: | Bexarotene has been used: • to investigate its effects on the changes in renal, cardiac, hepatic, and pulmonary expression/activity of inducible nitric oxide synthase (iNOS) and CYP4F6 • to analyze the involvement of retinoid x receptor (RXR) homo or permissive heterodimers • to study its potential impurities in drug substances and drug products |
| Biochem/physiol Actions: | Bexarotene is a highly selective retinoid X receptor (RXR) agonist. It is an antineoplastic agent, already approved as an oral antineoplastic agent for cutaneous T cell lymphoma and being investigated against other cancers. A study has found that bexarotene in a mouse Alzheimer′s model lowered the most toxic form of β-amyloid peptide and increased cognitive ability. The activity in the mouse Alzheimer′s models are believed to be by activating PPARγ:RXR and LXR:RXR dimers which induces the expression of apoE and facilitates Aβ clearance and promotes microglial phagocytosis. |
| Biochem/physiol Actions: | Bexarotene is used to treat breast cancer. |
| Features and Benefits: | This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 41106305 |