680C91
SIGMA/SML0287 - ≥98% (HPLC)
Synonym: 6-
CAS Number: 163239-22-3
Empirical Formula (Hill Notation): C15H11FN2
Molecular Weight: 238.26
MDL Number: MFCD20926361
Linear Formula: C15H11FN2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C15H11FN2/c16-13-5-6-1 |
| InChI key | YBSDQTBCNYWBMX-ONEGZZNKSA |
| Quality Level | 100  |
| SMILES string | Fc1ccc2c(C=Cc3cccnc3)c[ |
| solubility | DMSO: ≥10 mg/mL |
| storage temp. | 2-8°C |
| Application: | 680C91 has been used: • as a tryptophan 2,3 dioxygenase (TDO) inhibitor to study its effects on the pigmentation in Doryteuthis pealeii embryos • as a TDO inhibitor to study its effects on esophageal squamous cell carcinoma in xenograft tumor assay • as a tryptophan 2,3 dioxygenase 2 (TDO2) inhibitor to study its effects on toxic fragment formation in human embryonic kidney cells |
| Biochem/physiol Actions: | 680C91 is a potent inhibitor of the enzyme tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin. Kynurenin has recently been identified as an endogenous lignd of the arylhydrocarbon receptor (AHR). TDO is highly expressed in glioma cells, and contributes to AHR-mediated glioma cell survival and suppression of anti-tumor immune responses. |
| Biochem/physiol Actions: | 680C91 shows no inhibitory effects against monoamine oxidase A and B, indoleamine 2,3-dioxygenase and serotonin (5-HT) uptake, and 5-HT1A,1D,2A, and 2C receptors. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS05 |
| Signal word | Danger |
| Hazard statements | H318 |
| Precautionary statements | P280 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 41 |
| Safety Statements | 26-39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |