Nepafenac
SIGMA/SML0288 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 78281-72-8
Empirical Formula (Hill Notation): C15H14N2O2
Molecular Weight: 254.28
MDL Number: MFCD08067732
Linear Formula: C15H14N2O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | faintly yellow to dark yellow |
form | powder |
InChI | 1S/C15H14N2O2/c16-13(18)9 |
InChI key | QEFAQIPZVLVERP-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | NC(=O)Cc1cccc(c1N)C(=O)c2 |
solubility | DMSO: ≥5 mg/mL |
storage temp. | room temp |
Biochem/physiol Actions: | Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery. |
Biochem/physiol Actions: | Nepafenac, a prodrug of amfenac, is used in the treatment of diabetic retinopathy. It is metabolized to its active form through intraocular enzymatic hydrolysis. Nepafenac has a molecular weight of 254.28 kDa and effectively penetrates through the cornea. Its molecule structure enables nepafenac to possess better permeability. Nepafenac has a low inhibitory effect on cyclooxygenase. |
Packaging: | 10, 50 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H400 |
Precautionary statements | P273 |
Hazard Codes | N |
Risk Statements | 50/53 |
Safety Statements | 60-61 |
RIDADR | UN 3077 9 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | room temp |
UNSPSC | 12352200 |