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MLS000389544

SIGMA/SML0290 - ≥98% (HPLC)

Synonym: 4-(Methylsulfonyl)-3-nitro-benzoic acid 2-oxo-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethyl ester; MLS-389544; [2-(1-Adamantylamino)-2-oxoethyl] 4-methylsulfonyl-3-nitrobenzoate

CAS Number: 573965-48-7
Empirical Formula (Hill Notation): C20H24N2O7S
Molecular Weight: 436.48
Linear Formula: C20H24N2O7S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0290-5MG 5 mg
 $138.00
1/EA		 Add To Favorites
45-SML0290-25MG 25 mg
 $552.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H24N2O7S/c1-30(27,28)17-3-2-15(7-16(17)22(25)26)19(24)29-11-18(23)21-20-8-12-4-13(9-20)6-14(5-12)10-20/h2-3,7,12-14H,4-6,8-11H2,1H3,(H,21,23)
InChI key BTXTVUJWNPMQBT-UHFFFAOYSA-N
Quality Level 100 
SMILES string CS(=O)(=O)c1ccc(cc1[N+]([O-])=O)C(=O)OCC(=O)NC23CC4CC(CC(C4)C2)C3
solubility H2O: ≥5 mg/mL (warmed)
storage temp. −20°C
Biochem/physiol Actions: MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2).
Biochem/physiol Actions: MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2). It effectively block TR-mediated gene transcription. MLS000389544 is selective for TR over other NR family members. It appears to act by irreversible mechanisms and target cysteine residues in the coactivator binding pocket.
Features and Benefits: This compound is featured on the Nuclear Receptors (Non-Steroids)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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