Synonym: (3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester; (3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate; CID24856225
CAS Number: 1073529-41-5
Empirical Formula (Hill Notation): C17H20N2O5
Molecular Weight: 332.35
MDL Number: MFCD28053514
Linear Formula: C17H20N2O5
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
colorless |
| form |
film |
| InChI |
1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1 |
| InChI key |
ZRHWCAFAIHTQKD-KRWDZBQOSA-N |
| Quality Level |
100  |
| SMILES string |
O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O |
| solubility |
DMSO: ≥5 mg/mL |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). |
| Biochem/physiol Actions: |
ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
