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Biphalin trifluoroacetate salt

SIGMA/SML0299 - ≥97% (HPLC)

Synonym: 1,2-Bis(L-Tyr-D-Ala-Gly-L-Phe-)hydrazine; L-Tyrosyl-D-alanylglycyl-L-phenylalanine 2-(L-tyrosyl-D-alanylglycyl-L-phenylalanyl)hydrazide

CAS Number: 126872-95-5
Empirical Formula (Hill Notation): C46H56N10O10 · xC2HF3O2
Molecular Weight: 909.00 (free base basis)
MDL Number: MFCD23380198
Linear Formula: C46H56N10O10 · xC2HF3O2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML0299-1MG 1 mg
$305.00
1/EA
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assay ≥97% (HPLC)
color white to beige
form lyophilized solid
InChI 1S/C46H56N10O10.C2HF3O2/c1-27(51-43(63)35(47)21-31-13-17-33(57)18-14-31)41(61)49-25-39(59)53-37(23-29-9-5-3-6-10-29)45(65)55-56-46(66)38(24-30-11-7-4-8-12-30)54-40(60)26-50-42(62)28(2)52-44(64)36(48)22-32-15-19-34(58)20-16-32;3-2(4,5)1(6)7/h3-20,27-28,35-38,57-58H,21-26,47-48H2,1-2H3,(H,49,61)(H,50,62)(H,51,63)(H,52,64)(H,53,59)(H,54,60)(H,55,65)(H,56,66);(H,6,7)/t27-,28-,35+,36+,37+,38+;/m1./s1
InChI key KNKVMVJCRGCBFW-GJLSYRFBSA-N
Quality Level 100 
shipped in wet ice
SMILES string OC(=O)C(F)(F)F.C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)NNC(=O)[C@H](Cc3ccccc3)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc4ccc(O)cc4
storage temp. −20°C
Amino Acid Sequence: (Tyr-DAla-Gly-Phe-NH)2
Biochem/physiol Actions: Biphalin is a dimeric enkephalin that is a potent and non-selective opioid receptors (OR) agonist. It displays a high analgesic potency that is over 1000-fold greater than morphine. Studies show that biphalin exhibits neuroprotective effects in rat models of stroke.
Biochem/physiol Actions: Biphalin trifluoroacetate salt, a highly active synthetic octapeptide, is an analog of biphalin. It displays a strong affinity in the nanomolar range for the receptors μ and δ.
Features and Benefits: This compound is featured on the Opioid Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 1 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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