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Pimelic Diphenylamide 106

SIGMA/SML0313 - ≥98% (HPLC)

Synonym: Compound 106; Inhibitor 106; N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide; RGFA 8; TC-H 106

CAS Number: 937039-45-7
Empirical Formula (Hill Notation): C20H25N3O2
Molecular Weight: 339.43
MDL Number: MFCD17010287
Linear Formula: C20H25N3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0313-5MG 5 mg
 $98.60
1/EA		 Add To Favorites
45-SML0313-25MG 25 mg
 $385.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
InChI key WTKBRPXPNAKVEQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1
solubility DMSO: ≥15 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: 106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.
Biochem/physiol Actions: 106 is a potent Class I HDAC inhibitor, demonstrating no activity against class II HDACs.
Biochem/physiol Actions: Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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