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CGP77675

SIGMA/SML0314 - ≥98% (HPLC)

Synonym: 1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol; 1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol; CGP 77675; CGP-77675

CAS Number: 234772-64-6
Empirical Formula (Hill Notation): C26H29N5O2
Molecular Weight: 443.54
MDL Number: MFCD20039929
Linear Formula: C26H29N5O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0314-5MG 5 mg
 $162.00
1/EA		 Add To Favorites
45-SML0314-25MG 25 mg
 $649.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)
InChI key WUPXZZWTHIZICK-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25
solubility DMSO: >10 mg/mL
storage temp. 2-8°C
Application: CGP77675 has been used in the generation of mouse expanded potential stem cells.
Biochem/physiol Actions: CGP77675 is a potent Src kinase inhibitor.
Biochem/physiol Actions: CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold).
Biochem/physiol Actions: CGP77675 prevents hypercalcemia stimulated by interleukin 1β. It is known to offer protection against bone loss in ovariectomized mice. CGP77675 is known for its use in cancer treatment.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: CGP77675 belongs to the pyrrolopyrimidine class of inhibitors.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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