CORM-A1
SIGMA/SML0315 - ≥95% (NMR)
Synonym: Sodium boranocarbonate
CAS Number: 17363-08-5
Empirical Formula (Hill Notation): CH3BNa2O2
Molecular Weight: 103.82
MDL Number: MFCD18839226
Linear Formula: CH3BNa2O2
Product Type: Chemical
| assay | ≥95% (NMR) |
| color | white to beige |
| form | powder |
| InChI | 1S/CH4BO2.2Na/c2-1(3)4;;/ |
| InChI key | SOFPSQNQOQPAAJ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [Na+].[Na+].[BH3-]C([O-]) |
| solubility | H2O: >15 mg/mL |
| storage condition | desiccated |
| storage temp. | room temp |
| Application: | CORM-A1 has been used: • to deliver carbon monoxide (CO) and to test its cytoprotection in yeast and primary astrocytes culture during oxidative stress • as CO donor in murine macrophages J774A.1 cells to test its effect on cellular β-endorphins elevation • to test its effect on mitophagy activation in retinal ganglion cells |
| Biochem/physiol Actions: | CORM-A1 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase is an important gaseous signaling mediator in mammalian cells CORM-A1 has anti-oxidant and anti-inflammatory activity. |
| Biochem/physiol Actions: | CORM-A1 is a water-soluble carbon monoxide (CO) releasing molecule. |
| Biochem/physiol Actions: | It mediates the release of CO in a pH and temperature-dependent manner, thus favoring mild vasorelaxation and hypotension. During oxidative stress, CORM-A1 is reported to provide cytoprotection in astrocyte primary cultures. This boron-containing CORM promotes autophagy. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (NMR) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |