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Caramiphen hydrochloride

SIGMA/SML0319 - ≥98% (HPLC)

Synonym: 2-(Diethylamino)ethyl 1-phenylcyclopentane-1-carboxylate hydrochloride; Caramiphenium chloride salt; G 2747; Panparnit; Parpanil; Parpanit; Pentaphen; Pentaphene hydrochloride

CAS Number: 125-85-9
Empirical Formula (Hill Notation): C18H27NO2 · HCl
Molecular Weight: 325.87
MDL Number: MFCD00242608
Linear Formula: C18H27NO2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0319-10MG 10 mg
 $228.00
1/EA		 Add To Favorites
45-SML0319-50MG 50 mg
 $621.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H27NO2.ClH/c1-3-19(4-2)14-15-21-17(20)18(12-8-9-13-18)16-10-6-5-7-11-16;/h5-7,10-11H,3-4,8-9,12-15H2,1-2H3;1H
InChI key MUPNXGNOIBYHSG-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.CCN(CC)CCOC(=O)C1(CCCC1)c2ccccc2
solubility H2O: ≥5 mg/mL
storage temp. 2-8°C
Application: Caramiphen hydrochloride has been used to test its inhibitory effect on voltage-gated Na+ currents using the patch-clamp method.
Biochem/physiol Actions: Caramiphen hydrochloride is non-narcotic and possesses many biological functionalities of being antitussive, anticonvulsive, and neuroprotective. It induces sensory block and displays less toxicity when compared to bupivacaine. The local anesthetic functionality of caramiphen is mediated by its inhibitory effect on voltage-gated Na+ currents.
Biochem/physiol Actions: Caramiphen is a muscarinic acetylcholine receptor antagonist.
Biochem/physiol Actions: Caramiphen is an anti-muscarinic similar to atropine; muscarinic acetylcholine receptor antagonist. Caramiphen is commonly used as a cough suppresant, but is also administered for the treatment of Parkinson′s disease. The compound has also been shown to have anti-depressant properties that may involve inhibition of G protein-coupled inwardly rectifying potassium channel GIRK.
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Muscarinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10, 50 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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