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FR180204

SIGMA/SML0320 - ≥98% (HPLC)

Synonym: 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine; 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine; FR 180204

CAS Number: 865362-74-9
Empirical Formula (Hill Notation): C18H13N7
Molecular Weight: 327.34
MDL Number: MFCD14585805
Linear Formula: C18H13N7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0320-5MG 5 mg
 $170.00
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45-SML0320-25MG 25 mg
 $649.00
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assay ≥98% (HPLC)
color faintly yellow to dark yellow
form powder
InChI 1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)
InChI key XVECMUKVOMUNLE-UHFFFAOYSA-N
Quality Level 100 
SMILES string Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5
solubility DMSO: ≥10 mg/mL
storage temp. 2-8°C
Application: FR180204 has been used as ERK inhibitor:
• to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
• of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
•  to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy
Biochem/physiol Actions: FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).
Biochem/physiol Actions: FR180204 is a potent, selective, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2.
Biochem/physiol Actions: It can be used to study the roles of ERK as well as for drug development.
Features and Benefits: This compound is featured on the MAPKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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