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SR1001

SIGMA/SML0322 - ≥98% (HPLC)

Synonym: N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide

CAS Number: 1335106-03-0
Empirical Formula (Hill Notation): C15H13F6N3O4S2
Molecular Weight: 477.40
MDL Number: MFCD23160036
Linear Formula: C15H13F6N3O4S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0322-5MG 5 mg
 $148.00
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45-SML0322-25MG 25 mg
 $491.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C15H13F6N3O4S2/c1-7-11(29-12(22-7)23-8(2)25)30(27,28)24-10-5-3-9(4-6-10)13(26,14(16,17)18)15(19,20)21/h3-6,24,26H,1-2H3,(H,22,23,25)
InChI key OZBSSKGBKHOLGA-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC(=O)Nc1nc(C)c(s1)S(=O)(=O)Nc2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F
solubility DMSO: >5 mg/mL
storage temp. 2-8°C
Application: SR1001 has been used as retinoic-acid receptor (RAR)-related orphan nuclear receptor gamma (RORγt) inhibitor to study its effects on interleukin 17 (IL-17) expression in itch cells , as a RAR-related orphan receptor alpha (RORα)- inhibitor to study its effects on RORα-dependent transcription of glucose-6-phosphatase (G6Pase) .
Application: SR1001 has been used for inhibiting retinoid-related orphan receptor-γ t (RORγT) activation in Itch−/− mice.
Biochem/physiol Actions: SR1001 is a RORα/RORγt antagonist with no activity at LXR or RORβ; suppressor of TH17 cell differentiation and autoimmunity.
Biochem/physiol Actions: SR1001 is an antagonist of the nuclear retinoic acid receptor-related orphan receptors RORα and RORγt with no activity at LXR or RORβ. RORα and RORγt are essential for the development of TH17 cells, T-helper cells that produce interleukin-17 and have recently been shown to have pathological roles in various autoimmune diseases. SR1001 binds to the ligand-binding domain of RORα and RORγt to decrease affinity of the receptor for coactivators and increse affinity for co-repressors. It inhibited the differentiation and function of TH17 cells and suppressed the clinical severity of a mouse model of multiple sclerosis.
Features and Benefits: This compound is featured on the Nuclear Receptors (PPARs)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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