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SMI-4a

SIGMA/SML0323 - ≥98% (HPLC)

Synonym: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione; (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione

CAS Number: 438190-29-5
Empirical Formula (Hill Notation): C11H6F3NO2S
Molecular Weight: 273.23
MDL Number: MFCD01152003
Linear Formula: C11H6F3NO2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0323-10MG 10 mg
 $0.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-
InChI key NGJLOFCOEOHFKQ-YVMONPNESA-N
Quality Level 100 
SMILES string FC(F)(F)c1cccc(C=C2/SC(=O)NC2=O)c1
solubility DMSO: >10 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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