SMI-4a
SIGMA/SML0323 - ≥98% (HPLC)
Synonym: (5Z)
CAS Number: 438190-29-5
Empirical Formula (Hill Notation): C11H6F3NO2S
Molecular Weight: 273.23
MDL Number: MFCD01152003
Linear Formula: C11H6F3NO2S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C11H6F3NO2S/c12-11(13, |
InChI key | NGJLOFCOEOHFKQ-YVMONPNESA |
Quality Level | 100 ![]() |
SMILES string | FC(F)(F)c1cccc(C=C2/SC(= |
solubility | DMSO: >10 mg/mL |
storage temp. | 2-8°C |
Biochem/physiol Actions: | SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines. |
Packaging: | 10, 50 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H317-H319 |
Precautionary statements | P280-P305 + P351 + P338 |
Hazard Codes | Xi |
Risk Statements | 36-43 |
Safety Statements | 26-36/37 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |