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GTS-21

SIGMA/SML0326 - ≥97% (HPLC)

Synonym: 3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride; DMBX-anabaseine; DMXB; DMXB-A; GTS21

CAS Number: 156223-05-1
Empirical Formula (Hill Notation): C19H20N2O2 · 2HCl
Molecular Weight: 381.30
MDL Number: MFCD00941364
Linear Formula: C19H20N2O2 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0326-5MG 5 mg
 $93.00
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45-SML0326-25MG 25 mg
 $380.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color faintly yellow to dark yellow
form powder
InChI 1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
InChI key BXKYFUGAAFLYJL-BXGYHSFXSA-N
Quality Level 100 
SMILES string Cl.Cl.COc1ccc(C=C2/CCCN=C2c3cccnc3)c(OC)c1
solubility H2O: >5 mg/mL
storage temp. 2-8°C
Application: GTS-21 has been used:
• as an α7 nicotinic acetylcholine receptors (nAChR) partial agonist to elucidate its anti-inflammatory effects in mouse macrophages
• to test its protective effect on the renal injury induced by lipopolysaccharide (LPS)
• to test its effect on microvascular inflammation in endotoxemia induced by LPS
Biochem/physiol Actions: GTS-2, a derivative of anisine is an immunomodulatory drug. It is used for treating pancreatitis and septicemia. GTS-2 inhibits the pro-inflammatory cytokines especially the interleukin-6 (IL6) and tumor necrosis factor (TNF) in sepsis and endotoxemia.
Biochem/physiol Actions: GTS-21 is a selective agonist at α-7 nicotinic receptors with anti-inflammatory and cognition enhancing activities. GTS-21 has also been investigated for the treatment of schizophrenia.
Biochem/physiol Actions: GTS-21 is a selective agonist at α-7 nicotinic receptors.
Features and Benefits: This compound is featured on the Acetylcholine Receptors (Nicotinic)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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