GTS-21
SIGMA/SML0326 - ≥97% (HPLC)
Synonym: 3-
CAS Number: 156223-05-1
Empirical Formula (Hill Notation): C19H20N2O2 · 2HCl
Molecular Weight: 381.30
MDL Number: MFCD00941364
Linear Formula: C19H20N2O2 · 2HCl
Product Type: Chemical
assay | ≥97% (HPLC) |
color | faintly yellow to dark yellow |
form | powder |
InChI | 1S/C19H20N2O2.2ClH/c1-22- |
InChI key | BXKYFUGAAFLYJL-BXGYHSFXSA |
Quality Level | 100 ![]() |
SMILES string | Cl.Cl.COc1ccc(C=C2/CCCN= |
solubility | H2O: >5 mg/mL |
storage temp. | 2-8°C |
Application: | GTS-21 has been used: • as an α7 nicotinic acetylcholine receptors (nAChR) partial agonist to elucidate its anti-inflammatory effects in mouse macrophages • to test its protective effect on the renal injury induced by lipopolysaccharide (LPS) • to test its effect on microvascular inflammation in endotoxemia induced by LPS |
Biochem/physiol Actions: | GTS-2, a derivative of anisine is an immunomodulatory drug. It is used for treating pancreatitis and septicemia. GTS-2 inhibits the pro-inflammatory cytokines especially the interleukin-6 (IL6) and tumor necrosis factor (TNF) in sepsis and endotoxemia. |
Biochem/physiol Actions: | GTS-21 is a selective agonist at α-7 nicotinic receptors with anti-inflammatory and cognition enhancing activities. GTS-21 has also been investigated for the treatment of schizophrenia. |
Features and Benefits: | This compound is featured on the Acetylcholine Receptors (Nicotinic) ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |