AM630
SIGMA/SML0327 - ≥90% (HPLC)
Synonym: 6-
CAS Number: 164178-33-0
Empirical Formula (Hill Notation): C23H25IN2O3
Molecular Weight: 504.36
MDL Number: MFCD01861183
Linear Formula: C23H25IN2O3
Product Type: Chemical
| assay | ≥90% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C23H25IN2O3/c1-16-22(2 |
| InChI key | JHOTYHDSLIUKCJ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | COc1ccc(cc1)C(=O)c2c(C)n( |
| solubility | DMSO: >5 mg/mL |
| storage condition | desiccated |
| storage temp. | 2-8°C |
| Application: | AM630 has been used: • as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from Trametes versicolor (TPSP). • as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells. • as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts. |
| Biochem/physiol Actions: | AM630 is a selective CB2 cannabinoid antagonist/inverse agonist (Ki = 31.2 nM) with > 150-fold selectivity over CB1 receptors. |
| Biochem/physiol Actions: | AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hy |
| Features and Benefits: | This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS09 |
| Signal word | Warning |
| Hazard statements | H410 |
| Precautionary statements | P273 - P501 |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |