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Carcinine dihydrochloride

SIGMA/SML0329 - ≥98% (HPLC)

Synonym: β-Alanylhistamine dihydrochloride; 3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide dihydrochloride; Alistin; Beta-Alanylhistamine dihydrochloride

CAS Number: 57022-38-5
Empirical Formula (Hill Notation): C8H14N4O · 2HCl
Molecular Weight: 255.14
MDL Number: MFCD22200567
Linear Formula: C8H14N4O · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0329-5MG 5 mg
 $101.00
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45-SML0329-25MG 25 mg
 $393.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C8H14N4O.2ClH/c9-3-1-8(13)11-4-2-7-5-10-6-12-7;;/h5-6H,1-4,9H2,(H,10,12)(H,11,13);2*1H
InChI key ZQTUNIWBUQUKAM-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.Cl.NCCC(=O)NCCc1cnc[nH]1
solubility H2O: >15 mg/mL
storage condition desiccated
storage temp. −20°C
Application: Carcinine dihydrochloride has been used to study its effects on dopaminergic neuron degeneration.
Biochem/physiol Actions: Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins.
Biochem/physiol Actions: Carcinine can scavenge a toxic product, called 4-hydroxynonenal (4-HNE), obtained during lipid oxidation. It has a protective role from oxidative damage on photoreceptor cells. Carcinine also exhibits lipid-peroxidase activity.
Biochem/physiol Actions: Carcinine is a selective histamine H3 antagonist; antioxidant.
Features and Benefits: This compound is featured on the Histamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Carcinine, a natural peptide derivative, with a β-alanyl residue and a histamine, carries an imidazole ring. In mammals, carcinine is present in the brain, muscle, intestine and liver tissues.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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