S3I-201
SIGMA/SML0330 - ≥97% (HPLC)
Synonym: 2-
CAS Number: 501919-59-1
Empirical Formula (Hill Notation): C16H15NO7S
Molecular Weight: 365.36
MDL Number: MFCD09907564
Linear Formula: C16H15NO7S
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C16H15NO7S/c1-10-2-5-1 |
InChI key | HWNUSGNZBAISFM-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | Cc1ccc(cc1)S(=O)(=O)OCC(= |
solubility | DMSO: >10 mg/mL |
storage temp. | −20°C |
Application: | S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor: • to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s) • to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines • to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells |
Biochem/physiol Actions: | Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease. |
Biochem/physiol Actions: | S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activatio |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |