S3I-201

SIGMA/SML0330 - ≥97% (HPLC)

Synonym: 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid; NSC 74859

CAS Number: 501919-59-1
Empirical Formula (Hill Notation): C₁₆H₁₅NO₇S
Molecular Weight: 365.36
MDL Number: MFCD09907564
Linear Formula: C₁₆H₁₅NO₇S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0330-5MG	5 mg	$110.00 1/EA	Add To Favorites
45-SML0330-25MG	25 mg	$463.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to beige
form	powder
InChI	1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChI key	HWNUSGNZBAISFM-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
solubility	DMSO: >10 mg/mL
storage temp.	−20°C

Application:	S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor: • to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s) • to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines • to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells
Biochem/physiol Actions:	Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.
Biochem/physiol Actions:	S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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