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S3I-201

SIGMA/SML0330 - ≥97% (HPLC)

Synonym: 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid; NSC 74859

CAS Number: 501919-59-1
Empirical Formula (Hill Notation): C16H15NO7S
Molecular Weight: 365.36
MDL Number: MFCD09907564
Linear Formula: C16H15NO7S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0330-5MG 5 mg
 $113.00
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45-SML0330-25MG 25 mg
 $476.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChI key HWNUSGNZBAISFM-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
solubility DMSO: >10 mg/mL
storage temp. −20°C
Application: S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
• to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
•  to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
• to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells
Biochem/physiol Actions: Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.
Biochem/physiol Actions: S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.
Biochem/physiol Actions: S3I-201 is a cell-permeable Stat3 inhibitor.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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