NVP-BHG712

SIGMA/SML0333 - ≥98% (HPLC)

Synonym: 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]-benzamide

CAS Number: 940310-85-0
Empirical Formula (Hill Notation): C₂₆H₂₀F₃N₇O
Molecular Weight: 503.48
MDL Number: MFCD20272929
Linear Formula: C₂₆H₂₀F₃N₇O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0333-5MG	5 mg	$158.00 1/EA	Add To Favorites
45-SML0333-25MG	25 mg	$661.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)
InChI key	ZCCPLJOKGAACRT-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cc1ccc(cc1Nc2nc(nc3n(C)ncc23)-c4cccnc4)C(=O)Nc5cccc(c5)C(F)(F)F
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C

Application:	NVP-BHG712 has been used as an ephrin type-B receptor 4 (Eph-B4) inhibitor to study its effect on Eph-B4 phosphorylation in ephrin-B2/Fc stimulated mouse lung endothelial cells.
Application:	NVP-BHG712 has been used as an epinephrine type-B receptor 4 (Eph-B4) inhibitor: • to study its effects on human colorectal cancer cell growth in vitro and the growth of tumor cells in mice. • to study the regulation of endothelial nitric oxide synthase. • to study its effects on vascularization and growth of endometriotic lesions.
Biochem/physiol Actions:	NVP-BHG712 (4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide) inhibits the activity of ABC transporter subfamily C member 10 (ABCC10), which is responsible for mediating paclitaxel resistance. Therefore, NVP-BHG712 in combination with paclitaxel is effective against cancers that are resistant to paclitaxel due to the expression of the ABCC10.
Biochem/physiol Actions:	NVP-BHG712 is a very potent, selective inhbitor of the receptor tyrosine kinase EphB4 (ED₅₀ = 25 nM). NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.
Biochem/physiol Actions:	NVP-BHG712 obstructs angiogenesis mediated by vascular endothelial growth factor in vivo. It also blocks the efflux of ATP-binding cassette (ABC) transporter subfamily C member 10 (ABCC10) into the HEK293 cells by overexpressing the ABCC10 transporter.
Features and Benefits:	This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Eph page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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