Tideglusib
SIGMA/SML0339 - ≥98% (HPLC)
Synonym: 4-
CAS Number: 865854-05-3
Empirical Formula (Hill Notation): C19H14N2O2S
Molecular Weight: 334.39
MDL Number: MFCD18633296
Linear Formula: C19H14N2O2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C19H14N2O2S/c22-18-20( |
| InChI key | PMJIHLSCWIDGMD-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O=C1SN(C(=O)N1Cc2ccccc2)c |
| solubility | DMSO: >15 mg/mL |
| storage temp. | 2-8°C |
| Application: | Tideglusib has been used: • as a reference compound in ADP-GloTM Kinase assay • as an allosteric inhibitor of GSK-3β to study its effects on myocardial remodeling and angiogenesis • as a differentiation agent (specifically a glycogen synthase kinase (GSK)-3β inhibitor) to convert fibroblast cells into octamer-binding transcription factor-4 (OCT4)+ and vascular endothelial growth factor receptor-2 (VEGFR-2/fetal liver kinase-1 (FLK1)+ cells |
| Biochem/physiol Actions: | Tideglusib is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3). |
| Biochem/physiol Actions: | Tideglusib, also known as NP031112 or NP-12, is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3), an important kinase studied in stem cell research and neurodegenerative diseases. It is currently in clinical trials for Alzheimer′s disease and Progressive Supranuclear Palsy (PSP). Tideglusib reduces phosphorylation of the tau protein and the accumulation of amyloid plaques, reduces hippocampal and entorhinal cortex neuron loss and improves spatial memory deficits. It has also shown neuroprotective and anti-inflammatory activity in a variety of animal models. |
| Features and Benefits: | This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |