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Importazole

SIGMA/SML0341 - ≥98% (HPLC)

Synonym: N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine

CAS Number: 662163-81-7
Empirical Formula (Hill Notation): C20H22N4
Molecular Weight: 318.42
MDL Number: MFCD04077630
Linear Formula: C20H22N4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0341-5MG 5 mg
 $131.00
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45-SML0341-25MG 25 mg
 $519.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)
InChI key HKGJEZIGDHFJFL-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC(C1=CC=CC=C1)NC2=NC(N3CCCC3)=NC4=C2C=CC=C4
solubility DMSO: >5 mg/mL
storage temp. 2-8°C
Application: Importazole has been used:
• to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
• to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
• as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
• as a functional inhibitor of Importin β in embryo treatment
• as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS
Biochem/physiol Actions: Importazole is an inhibitor of importin-β transport receptors.
Biochem/physiol Actions: Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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