Importazole
SIGMA/SML0341 - ≥98% (HPLC)
Synonym: N-
CAS Number: 662163-81-7
Empirical Formula (Hill Notation): C20H22N4
Molecular Weight: 318.42
MDL Number: MFCD04077630
Linear Formula: C20H22N4
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C20H22N4/c1-15(16-9-3- |
| InChI key | HKGJEZIGDHFJFL-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC(C1=CC=CC=C1)NC2=NC(N3C |
| solubility | DMSO: >5 mg/mL |
| storage temp. | 2-8°C |
| Application: | Importazole has been used: • to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3) • to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect • as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery • as a functional inhibitor of Importin β in embryo treatment • as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS |
| Biochem/physiol Actions: | Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |