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Methylstat

SIGMA/SML0343 - ≥98% (HPLC)

Synonym: (2E)-4-[Hydroxy[4-[[[4-[[[(1-naphthalenylamino)carbonyl]oxy]methyl]phenyl]methyl]amino]butyl]amino]-4-oxo-2-butenoic acid methyl ester

CAS Number: 1310877-95-2
Empirical Formula (Hill Notation): C28H31N3O6
Molecular Weight: 505.56
MDL Number: MFCD22572723
Linear Formula: C28H31N3O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0343-5MG 5 mg
 $207.00
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45-SML0343-25MG 25 mg
 $790.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C28H31N3O6/c1-36-27(33)16-15-26(32)31(35)18-5-4-17-29-19-21-11-13-22(14-12-21)20-37-28(34)30-25-10-6-8-23-7-2-3-9-24(23)25/h2-3,6-16,29,35H,4-5,17-20H2,1H3,(H,30,34)/b16-15+
InChI key MUJOCHRZXRZONW-FOCLMDBBSA-N
Quality Level 100 
SMILES string O=C(NC1=CC=CC2=C1C=CC=C2)OCC3=CC=C(CNCCCCN(O)C(/C=C/C(OC)=O)=O)C=C3
solubility DMSO: >5 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs). Methylstat inhibits the activity of JMJD2C (IC50 = 4.3 μM), with similar potency against JMJD2E and JMJD3. The compound has poor activity against dimethyl demethylases, and does not inhibit class I or II HDACs. Methylsat blocks proliferation of the esophageal carcinoma cell line KYSE150 with an IC50 value of 5.1 μM.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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