Neferine

SIGMA/SML0349 - ≥98% (HPLC)

Synonym: (-)-Neferine; 4′′-O-Methylliensinine; 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol; Methylliensinine; Neferin

CAS Number: 2292-16-2
Empirical Formula (Hill Notation): C₃₈H₄₄N₂O₆
Molecular Weight: 624.77
MDL Number: MFCD22416529
Linear Formula: C₃₈H₄₄N₂O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML0349-5MG	5 mg	$124.00 1/EA	Add To Favorites
45-SML0349-25MG	25 mg	$486.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32+/m1/s1
InChI key	MIBATSHDJRIUJK-ZWXJPIIXSA-N
optical activity	[α]/D -34 to -44° (c=0 3. CHCl3)
Quality Level	100
SMILES string	COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(Oc4cc(C[C@@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc23)cc1
solubility	DMSO: >15 mg/mL
storage condition	desiccated
	protect from light
storage temp.	2-8°C

Application:	Neferine has been used to study its effect in autophagy signalling.
Biochem/physiol Actions:	Neferine inhibits proliferation of human osteosarcoma cells by stabilization of p21 through p38 MAPK-mediated activation; antidepressant-like and antiarrhythmic.
Biochem/physiol Actions:	Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
Features and Benefits:	This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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