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AZD-7762 hydrochloride

SIGMA/SML0350 - ≥98% (HPLC)

Synonym: 5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride; AZD 7762 hydrochloride

CAS Number: 1246094-78-9
Empirical Formula (Hill Notation): C17H19FN4O2S · HCl
Molecular Weight: 398.88
MDL Number: MFCD12546135
Linear Formula: C17H19FN4O2S · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0350-5MG 5 mg
 $131.00
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45-SML0350-25MG 25 mg
 $353.00
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assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1
InChI key WFZBLOIXZRZEDG-YDALLXLXSA-N
Quality Level 100 
SMILES string Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3
solubility DMSO: 15 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Application: AZD-7762 hydrochloride has been used:
• as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
• as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
• as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development
Biochem/physiol Actions: AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.
Biochem/physiol Actions: AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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