AZD-7762 hydrochloride
SIGMA/SML0350 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 1246094-78-9
Empirical Formula (Hill Notation): C17H19FN4O2S · HCl
Molecular Weight: 398.88
MDL Number: MFCD12546135
Linear Formula: C17H19FN4O2S · HCl
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to light brown |
form | powder |
InChI | 1S/C17H19FN4O2S.ClH/c18-1 |
InChI key | WFZBLOIXZRZEDG-YDALLXLXSA |
Quality Level | 100 |
SMILES string | Cl.NC(=O)Nc1cc(sc1C(=O)N[ |
solubility | DMSO: 15 mg/mL, clear |
storage condition | desiccated |
storage temp. | −20°C |
Application: | AZD-7762 hydrochloride has been used: • as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines • as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events • as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development |
Biochem/physiol Actions: | AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS05,GHS07 |
Signal word | Danger |
Hazard statements | H302 - H318 |
Precautionary statements | P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 |
Hazard Codes | Xn |
Risk Statements | 22-41 |
Safety Statements | 26-39 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |