PFI-1
SIGMA/SML0352 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 1403764-72-6
Empirical Formula (Hill Notation): C16H17N3O4S
Molecular Weight: 347.39
MDL Number: MFCD22580416
Linear Formula: C16H17N3O4S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C16H17N3O4S/c1-19-10-1 |
InChI key | TXZPMHLMPKIUGK-UHFFFAOYSA |
Quality Level | 100 ![]() |
SMILES string | COc1ccccc1S(=O)(=O)Nc2ccc |
solubility | DMSO: ≥10 mg/mL |
storage temp. | 2-8°C |
Application: | PFI-1 has been used as a bromodomain inhibitor in breast cancer cell line MCF7 dechorionated zebrafish embryos. It has also been used in human peripheral blood mononuclear cells (PBMCs), to inhibit the release of interleukin-6 in lipopolysaccharide (LPS) challenge assay. |
Biochem/physiol Actions: | PFI-1 is a quinazolinone inhibits androgen receptor (AR) mediated signaling in prostate cancer cells. It elicits minimum toxicity and is effective for anti-HIV-latency therapy. In leukemia cells, PFI-1 inhibits Aurora B kinase and promotes caspase-dependent apoptosis. |
Biochem/physiol Actions: | The human BET family, which includes BRD2, BRD3, BRD4 and BRDT, play a role in regulation of gene transcription. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). For full characterization details, please visit the PFI-1 probe summary ![]() ![]() To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc ![]() |
Features and Benefits: | PFI-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC ![]() |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here ![]() ![]() |
Other Notes: | PFI-1 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PFI-1 probe summary ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |