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Azimilide dihydrochloride

SIGMA/SML0353 - ≥97% (HPLC)

Synonym: 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride

CAS Number: 149888-94-8
Empirical Formula (Hill Notation): C23H28ClN5O3 · 2HCl
Molecular Weight: 530.88
Linear Formula: C23H28ClN5O3 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML0353-5MG 5 mg
 $120.00
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45-SML0353-25MG 25 mg
 $471.00
1/EA		 Add To Favorites

 

assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C23H28ClN5O3.2ClH/c1-26-11-13-27(14-12-26)9-2-3-10-28-22(30)17-29(23(28)31)25-16-20-7-8-21(32-20)18-5-4-6-19(24)15-18;;/h4-8,15-16H,2-3,9-14,17H2,1H3;2*1H/b25-16-;;
InChI key SUHOTCCGXXEWJN-DSHYBBOZSA-N
Quality Level 100 
SMILES string Cl.Cl.CN1CCN(CCCCN2C(=O)CN(N=C/c3ccc(o3)-c4cccc(Cl)c4)C2=O)CC1
solubility DMSO: 1 mg/mL, clear (warmed)
storage condition desiccated
storage temp. 2-8°C
Application: Azimilide dihydrochloride may be used in the electrophysiology experiments with human ether-a-go-go-related gene 1a (HERG1a) subunit.
Biochem/physiol Actions: Azimilide is a Class III antiarrhythmic; blocker of the delayed rectifier cardiac potassium channels; inhibits KV7.1 and KV11.1 potassium channels.
Biochem/physiol Actions: Azimilide is an inhibitor of human ether-a-go-go-related gene (HERG) channel. It displays a decrease in inhibitory effect in acidic pH conditions.
Biochem/physiol Actions: Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It inhibits KV7.1 and KV11.1 potassium channels. Azimilide′s block of K+ currents is relatively selective for IKr over IKs: It potently blocks the rapidly activating component of the delayed rectifier, IKr (IC50 0.4 mM), and inhibits IKs (IC50 3 mM) with nearly 10-fold less potency. At 10 mM, it does not block the inward rectifier K+ current. It blocks (10 mM) the L-type Ca2+ current (ICa) in a use-dependent manner.
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P264 - P270 - P301 + P310 - P405 - P501
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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