Azimilide dihydrochloride
SIGMA/SML0353 - ≥97% (HPLC)
Synonym: 1-
CAS Number: 149888-94-8
Empirical Formula (Hill Notation): C23H28ClN5O3 · 2HCl
Molecular Weight: 530.88
Linear Formula: C23H28ClN5O3 · 2HCl
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C23H28ClN5O3.2ClH/c1-2 |
InChI key | SUHOTCCGXXEWJN-DSHYBBOZSA |
Quality Level | 100 |
SMILES string | Cl.Cl.CN1CCN(CCCCN2C(=O)C |
solubility | DMSO: 1 mg/mL, clear (warmed) |
storage condition | desiccated |
storage temp. | 2-8°C |
Application: | Azimilide dihydrochloride may be used in the electrophysiology experiments with human ether-a-go-go-related gene 1a (HERG1a) subunit. |
Biochem/physiol Actions: | Azimilide is an inhibitor of human ether-a-go-go-related gene (HERG) channel. It displays a decrease in inhibitory effect in acidic pH conditions. |
Biochem/physiol Actions: | Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It inhibits KV7.1 and KV11.1 potassium channels. Azimilide′s block of K+ currents is relatively selective for IKr over IKs: It potently blocks the rapidly activating component of the delayed rectifier, IKr (IC50 0.4 mM), and inhibits IKs (IC50 3 mM) with nearly 10-fold less potency. At 10 mM, it does not block the inward rectifier K+ current. It blocks (10 mM) the L-type Ca2+ current (ICa) in a use-dependent manner. |
Features and Benefits: | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS06 |
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P264 - P270 - P301 + P310 - P405 - P501 |
Hazard Codes | T |
Risk Statements | 25 |
Safety Statements | 45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |